Recombinant human CH25H protein, N-His

Overview
Catalog #	bs-41322p-100ug
Product Name	Recombinant human CH25H protein, N-His
Applications	ELISA
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant human CH25H protein, N-His protein is expressed in E.coli with N-His. It contains the amino acid sequence of 140-272/272.
Storage Buffer	4M Urea (pH9.0) with 300mM NaCl.
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Swiss Prot	O95992
Background	CH25H (Cholesterol 25-hydroxylase), also known as h25OH, is a 272 amino acid endoplasmic membrane protein that belongs to the sterol desaturase family. CH25H contains clusters of histidine residues essential for catalytic activity and is involved in cholesterol and lipid metabolism. CH25H catalyzes the formation of 25-hydroxycholesterol from cholesterol leading to the repression of cholesterol biosynthetic enzymes. CH25H regulates lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. CH25H utilizes diiron cofactors to catalyze the hydroxylation of hydrophobic substrates.