Recombinant human RIPK1 protein, N-His

Overview
Catalog #	bs-42114p-100ug
Product Name	Recombinant human RIPK1 protein, N-His
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant human RIPK1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 327-564/671
Storage Buffer	0.01M TBS(pH7.4)
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	8737
Swiss Prot	Q13546
Background	Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.