Recombinant human JAK1 protein, His
Applications
Reactivity
| Overview | |
| Catalog # | bs-42216p-100ug |
| Product Name | Recombinant human JAK1 protein, His |
| Applications |
OTHERS
|
| Reactivity | Others |
| Specifications | |
| Conjugation | Unconjugated |
| Source | Recombinant human JAK1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 1-331/1154 |
| Storage Buffer | 20mM Tris-Hcl (pH=7.4) with 8M Urea. |
| Storage Condition | The product should be stored at -70°C or -20°C. |
| Target | |
| Gene ID | 3716 |
| Swiss Prot | P23458 |
| Background | Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. |
Frequently asked questions
How should bs-42216P be stored?
The product should be stored at -70°C or -20°C. Storage buffer: 20mM Tris-Hcl (pH=7.4) with 8M Urea.
How is Recombinant human JAK1 protein, His (bs-42216P) produced?
Recombinant human JAK1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 1-331/1154