Recombinant human Neutrophil Elastase protein
Applications
Reactivity
| Overview | |
| Catalog # | bs-42430P-100ug |
| Product Name | Recombinant human Neutrophil Elastase protein |
| Applications |
OTHERS
|
| Reactivity | Others |
| Specifications | |
| Conjugation | Unconjugated |
| Source | Recombinant human Neutrophil Elastase protein is expressed in E.coli with GST&His. It contains the amino acid sequence of 30-267/267 |
| Storage Buffer | 20mM Tris-Hcl (pH=8.0) with 8M Urea |
| Storage Condition | The product should be stored at -70°C or -20°C. |
| Target | |
| Gene ID | 1991 |
| Swiss Prot | P08246 |
| Background | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]. |