APH1a Polyclonal Antibody

Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti-APH1a gamma Polyclonal Antibody (bs-4259R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

$Formalin-fixed and paraffin-embedded rat brain labeled with Anti-APH1a Polyclonal Antibody, Unconjugated(bs-4259R) 1:200, overnight at 4\u00b0C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated(bs-0295G-Cy3)used at 1:200 dilution for 40 minutes at 37\u00b0C.$

Formalin-fixed and paraffin-embedded rat brain labeled with Anti-APH1a Polyclonal Antibody, Unconjugated(bs-4259R) 1:200, overnight at 4\u00b0C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated(bs-0295G-Cy3)used at 1:200 dilution for 40 minutes at 37\u00b0C.

Applications

WB
IHC-P
IF(IHC-P)

Reactivity

Human
Mouse
Rat

Overview
Catalog #	bs-4259R
Product Name	APH1a Polyclonal Antibody
Applications	WB, IHC-P, IF(IHC-P)
Reactivity	Human, Mouse, Rat
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human APH1a
Immunogen Range	90-118/265
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage	Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Target
Gene ID	51107
Swiss Prot	Q96BI3
Subcellular location	Cytoplasm
Synonyms	APH-1; APH-1A; CGI-78; 6530402N02Rik; Gamma-secretase subunit APH-1A; Aph-1alpha; Presenilin-stabilization factor; APH1A; PSF; UNQ579/PRO1141
Background	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Application Dilution
WB	1:300-1000
IHC-P	1:200-400
IF(IHC-P)	1:50-200

Applications

Reactivity

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