Recombinant SARS-Cov-2 Spike RBD protein (BQ.1.1/Omicron), His (HEK293), Biotin Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bs-43157P-Biotin-100ug |
| Product Name | Recombinant SARS-Cov-2 Spike RBD protein (BQ.1.1/Omicron), His (HEK293), Biotin Conjugated |
| Applications |
OTHERS
|
| Reactivity | Others |
| Specifications | |
| Conjugation | Biotin |
| Source | Recombinant SARS-Cov-2 Spike RBD protein (BQ.1.1/Omicron) is expressed in HEK293 cell with C-His. It contains the amino acid sequence of 319-537/1273 |
| Storage Buffer | Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization. |
| Target | |
| Swiss Prot | P0DTC2 |
| Background | The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The resulting mouse-adapted strain at passage 6 (called MASCp6) showed increased infectivity in mouse lung and led to interstitial pneumonia and inflammatory responses in both young and aged mice after intranasal inoculation. Deep sequencing revealed a panel of adaptive mutations potentially associated with the increased virulence. In particular, the N501Y mutation is located at the receptor binding domain (RBD) of the spike protein. |