Recombinant human FCGRT&B2M Heterodimer protein, C-His (HEK293)
Applications
Reactivity
| Overview | |
| Catalog # | bs-43201P-100ug |
| Product Name | Recombinant human FCGRT&B2M Heterodimer protein, C-His (HEK293) |
| Applications |
OTHERS
|
| Reactivity | Others |
| Specifications | |
| Conjugation | Unconjugated |
| Source | Recombinant human FCGRT&B2M Heterodimer protein is expressed in HEK293 cell with C-His. It contains the amino acid sequence of 24-297/365&21-119 |
| Storage Buffer | 0.01M TBS(pH7.4) |
| Storage Condition | The product should be stored at -70°C or -20°C. |
| Target | |
| Gene ID | 2217 |
| Swiss Prot | P55899 |
| Background | FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn å chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins. |