Recombinant mouse FCGRT&B2M Heterodimer protein, C-His (HEK293), APC Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bs-43206P-APC-100ug |
| Product Name | Recombinant mouse FCGRT&B2M Heterodimer protein, C-His (HEK293), APC Conjugated |
| Applications |
OTHERS
|
| Reactivity | Others |
| Specifications | |
| Conjugation | APC |
| Source | Recombinant mouse FCGRT&B2M Heterodimer protein is expressed in HEK293 cell with C-His. It contains the amino acid sequence of 22-297/365&21-119/119 |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Target | |
| Swiss Prot | P55899 |
| Background | FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn å chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins. |