Recombinant human TNFRSF14 protein, C-His (HEK293)
Applications
Reactivity
| Overview | |
| Catalog # | bs-43562p-100ug |
| Product Name | Recombinant human TNFRSF14 protein, C-His (HEK293) |
| Applications |
OTHERS
|
| Reactivity | Others |
| Specifications | |
| Conjugation | Unconjugated |
| Source | Recombinant human TNFRSF14 protein is expressed in HEK293 cell with C-His. It contains the amino acid sequence of 39-202/283 |
| Storage Buffer | 0.01M TBS(pH7.4) |
| Storage Condition | The product should be stored at -70°C or -20°C. |
| Target | |
| Gene ID | 8764 |
| Swiss Prot | Q92956 |
| Background | TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. |