| Overview |
| bs-4595R-PE |
| Collagen 4 Polyclonal Antibody, PE Conjugated |
| WB, FCM |
| Human, Mouse, Rat, Pig |
| Dog, Cow, Horse, Chicken, Rabbit |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Collagen alpha-1(IV) chain |
| 1571-1669/1669 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 1282 |
| P02462 |
| Secreted, Cell membrane, Extracellular matrix |
| ICH; HANAC; POREN1; arresten; Collagen alpha-1(IV) chain; COL4A1 |
| Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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