Recombinant human NGF-β protein (Active, HEK293)
Applications
Overview | |
Catalog # | bs-48035P |
Product Name | Recombinant human NGF-β protein (Active, HEK293) |
Applications | Others |
Specifications | |
Conjugation | Unconjugated |
Source | Recombinant human NGF-β protein is expressed in HEK293 |
Storage Buffer | 0.01M PBS(pH7.4) |
Storage Condition | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
Target | |
Gene ID | 4803 |
Swiss Prot | P01138 |
Background | Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF protein was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF (beta-NGF), was demonstrated to exhibits the growth-stimulating activity of NGF protein. NGFB/beta-NGF gene is a member of the NGF-beta family and encodes a secreted protein that homodimerizes and is incorporated into a larger complex. NGF protein acts via at least two receptors on the surface of cells (TrkA and p75 receptors) to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. Also, previous studies indicated that NGF may also have an important role in the regulation of the immune system. |