Mbd2 Polyclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bs-51058r |
| Product Name | Mbd2 Polyclonal Antibody |
| Applications |
WB
ELISA
|
| Reactivity | Mouse |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Polyclonal antibody raised in rabbit against mouse MBD2, using a KLH-conjugated synthetic peptide containing an amino acid sequence from the central part of the protein |
| Clonality | Polyclonal |
| Isotype | Not determined |
| Concentration | Not Determined |
| Purification | Whole antiserum from rabbit containing 0.05% azide |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C for 12 months. |
| Target | |
| Gene ID | 8932 |
| Swiss Prot | Q9UBB5 |
| Synonyms | Methyl-CpG-binding domain protein 2, MBD2, DMTase, Methyl-CpG-binding protein MBD2 |
| Background | Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. |
| Application Dilution | |
| WB | 1:300-5000 |
| ELISA | 1:500-1000 |