Jarid1b Polyclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bs-51067r |
| Product Name | Jarid1b Polyclonal Antibody |
| Applications |
WB
ELISA
|
| Reactivity | Mouse |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Polyclonal antibody raised in rabbit against mouse Jarid1b, using a KLH-conjugated synthetic peptides containing an amino acid sequence from the central part of the protein |
| Clonality | Polyclonal |
| Isotype | Not determined |
| Concentration | Not Determined |
| Purification | Whole antiserum from rabbit containing 0.05% azide |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C for 12 months. |
| Target | |
| Gene ID | 10765 |
| Swiss Prot | Q9UGL1 |
| Synonyms | CT31, PLU1, PUT1, RBBP2H1, RBP2-like |
| Background | Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). |
| Application Dilution | |
| WB | 1:300-5000 |
| ELISA | 1:500-1000 |