phospho-CREB-1 (Ser129) Polyclonal Antibody

Applications

WB
ELISA

Reactivity

Human
Mouse

Predicted Reactivity

Rat
Sheep
Pig
Horse

Overview
Catalog #	bs-5256R
Product Name	phospho-CREB-1 (Ser129) Polyclonal Antibody
Applications	WB ELISA
Reactivity	Human, Mouse
Predicted Reactivity	Rat, Sheep, Pig, Horse
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthetic phosphopeptide derived from human CREB-1 around the phosphorylation site of Ser129 [IL(p-S)RR]
Modification Site	Ser129
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID	1385
Subcellular location	Nucleus
Synonyms	CREBSer129; p-CREB-1Ser129; pCREB-1Ser129; Active transcription factor CREB; cAMP response element binding protein; cAMP responsive element binding protein 1; CREB1; CREB 1; CREB1; MGC9284; Transactivator protein; CREB; CREB1_HUMAN.
Background	The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1,ATF-2,ATF-3and ATF-4. these transcription factors share highly-related COOH terminal leucine zipper demerization and basic DNA bindings but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in cerain instances they also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. It has recentlybeen shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265kDa nuclear protein designated CBP (CREB-binding protein), which may reprecent a CREB co-activator.
Application Dilution
WB	1:300-5000
ELISA	1:500-1000