| Overview |
| bs-53080R |
| CBX3 Polyclonal Antibody |
| WB, ELISA |
| Human |
| Specifications |
| Unconjugated |
| Rabbit |
| Polyclonal antibody raised in rabbit against human CBX3 using two KLH-conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively |
| Polyclonal |
| #REF! |
| Not Determined |
| Not Determined |
| Whole antiserum from rabbit containing 0.05% azide |
| 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20C for 12 months. |
| Target |
| 11335 |
| Q13185 |
| Chromobox protein homolog 3, CBX3, HECH, Heterochromatin protein 1 homolog gamma, HP1 gamma,
Modifier 2 protein |
| Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. |
| Application Dilution |
| WB |
1:300-5000 |
| ELISA |
1:500-1000 |
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