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HP1 alpha Polyclonal Antibody

Applications

  • WB
  • IF

Reactivity

  • Human
Overview
Catalog # bs-53123R
Product Name HP1 alpha Polyclonal Antibody
Applications WB, IF
Reactivity Human
Specifications
Conjugation Unconjugated
Host Rabbit
Source Polyclonal antibody raised in rabbit against human HP1 alpha (Heterochromatin protein 1 homolog alpha), using the full length recombinant GST tagged protein
Clonality Polyclonal
Isotype Not Determined
Concentration 2ug/ul
Purification Protein G purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300
Storage Buffer PBS with 0.05% sodium azide and 0.05% Proclin300.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 23468
Swiss Prot P45973
Synonyms Chromobox protein homolog 5, CBX5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha, HP1A
Background Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Application Dilution
WB 1:300-5000
IF