| Overview |
| bs-5380R |
| NMDAR2B (Tyr1252) Polyclonal Antibody |
| WB, ELISA |
| This antibody may cross react with NMDAR2A (Tyr 1246) due to 75% sequence similarity. |
| Rat |
| Human, Mouse, Dog, Cow, Chicken, Rabbit, Guinea Pig |
| Specifications |
| Unconjugated |
| Rabbit |
| KLH conjugated synthetic phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1252 |
| Tyr1252 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Target |
| 2904 |
| Q13224 |
| Cell membrane |
| MRD6; NR2B; hNR3; GluN2B; NMDAR2B; Glutamate receptor ionotropic, NMDA 2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NR3; GRIN2B |
| NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). |
| Application Dilution |
| WB |
1:300-5000 |
| ELISA |
1:500-1000 |