NMDAR2B (Tyr1252) Polyclonal Antibody

Applications

  • WB
  • ELISA

Reactivity

  • Rat

Predicted Reactivity

  • Human
  • Mouse
  • Dog
  • Cow
  • Chicken
  • Rabbit
  • Guinea Pig
Overview
Catalog # bs-5380R
Product Name NMDAR2B (Tyr1252) Polyclonal Antibody
Applications WB, ELISA
Specificity This antibody may cross react with NMDAR2A (Tyr 1246) due to 75% sequence similarity.
Reactivity Rat
Predicted Reactivity Human, Mouse, Dog, Cow, Chicken, Rabbit, Guinea Pig
Specifications
Conjugation Unconjugated
Host Rabbit
Source KLH conjugated synthetic phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1252
Modification Site Tyr1252
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage Condition Store at -20°C for 12 months..
Target
Gene ID 2904
Swiss Prot Q13224
Subcellular location Cell membrane
Synonyms MRD6; NR2B; hNR3; GluN2B; NMDAR2B; Glutamate receptor ionotropic, NMDA 2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NR3; GRIN2B
Background NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
Application Dilution
WB 1:300-1000
ELISA 1:500-1000