DNMT1 Polyclonal Antibody

Applications

  • WB
  • IF(ICC)
  • IP
  • IF

Reactivity

  • Human
Overview
Catalog # bs-55056R
Product Name DNMT1 Polyclonal Antibody
Applications WB, IF(ICC), IP, IF
Specificity KO-Validated
Reactivity Human
Specifications
Conjugation Unconjugated
Host Rabbit
Source Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human DNMT1 (NP_001370.1).
Immunogen Range 1-270/1616
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID 1786
Swiss Prot P26358
Subcellular location Nucleus
Synonyms ADCADN;AIM;CXXC9;DNMT;HSN1E;MCMT;m.HsaI;DNMT1
Background This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
Application Dilution
WB 1:300-5000
IF(ICC) 1:50-200
IP 1-2ug
IF