MSH6 Polyclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bs-55135R |
| Product Name | MSH6 Polyclonal Antibody |
| Applications |
WB
IHC
IF
|
| Reactivity | Human, Mouse, Monkey |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human MSH6 (NP_000170.1). |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | Lot Dependent |
| Purification | purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C for 12 months. |
| Target | |
| Gene ID | 2956 |
| Swiss Prot | P52701 |
| Subcellular location | Nucleus |
| Synonyms | MSH6;GTBP;GTMBP;HNPCC5;HSAP;p160 |
| Background | This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. |
| Application Dilution | |
| WB | 1:300-5000 |
| IHC | 1:50-200 |
| IF | 1:50-200 |
Frequently asked questions
Which applications is MSH6 Polyclonal Antibody (bs-55135R) validated for, and at what dilution?
bs-55135R is validated for WB (1:300-5000); IHC (1:50-200); IF (1:50-200). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does MSH6 Polyclonal Antibody (bs-55135R) react with?
Tested reactivity: Human, Mouse, Monkey.
How should bs-55135R be stored?
Store at -20°C for 12 months. Storage buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise MSH6 Polyclonal Antibody (bs-55135R)?
Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human MSH6 (NP_000170.1).