PRKAR2A Polyclonal Antibody

Applications

  • WB
  • ELISA

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bs-55176R
Product Name PRKAR2A Polyclonal Antibody
Applications WB, ELISA
Specificity KO-Validated
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source Recombinant fusion protein containing a sequence corresponding to amino acids 1-404 of human PRKAR2A (NP_004148.1).
Immunogen Range 1-404/404
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 5576
Swiss Prot P13861
Subcellular location Cytoplasm, Cell membrane
Synonyms PRKAR2A;PKR2;PRKAR2
Background cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
Application Dilution
WB 1:300-1000
ELISA 1:500-1000