phospho-Girdin (Ser1417) Polyclonal Antibody

Applications

WB
ELISA
FCM

Reactivity

Human

Predicted Reactivity

Mouse
Rat
Dog
Cow
Pig
Horse

Overview
Catalog #	bs-6465R
Product Name	phospho-Girdin (Ser1417) Polyclonal Antibody
Applications	WB ELISA FCM
Reactivity	Human
Predicted Reactivity	Mouse, Rat, Dog, Cow, Pig, Horse
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthetic phosphopeptide derived from human Girdin around the phosphorylation site of Ser1417
Modification Site	Ser1417
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID	55704
Swiss Prot	Q3V6T2
Subcellular location	Cytoplasm, Cell membrane
Synonyms	APE; GIV; GRDN; HkRP1; GIRDIN; KIAA1212; Akt phosphorylation enhancer; Coiled-coil domain-containing protein 88A; G alpha-interacting vesicle-associated protein; Girders of actin filament; Hook-related protein 1; CCDC88A
Background	Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.
Application Dilution
WB	1:300-5000
ELISA	1:500-1000
FCM	1:20-100