Apo-1 Polyclonal Antibody

Applications

  • WB
  • ELISA
  • FCM

Reactivity

  • Human
  • Mouse
  • Rat

Predicted Reactivity

  • Pig
Overview
Catalog # bs-6477R
Product Name Apo-1 Polyclonal Antibody
Applications WB, ELISA, FCM
Reactivity Human, Mouse, Rat
Predicted Reactivity Pig
Specifications
Conjugation Unconjugated
Host Rabbit
Source KLH conjugated synthetic peptide derived from human FAS/Apo-1
Immunogen Range 81-170/335
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID 355
Swiss Prot P25445
Subcellular location Secreted, Cell membrane
Synonyms APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; FAS
Background Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Application Dilution
WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100