MRGPRX1/3/4 Polyclonal Antibody, Cy3 Conjugated

Applications

IF(IHC-P)
IF(IHC-F)
IF(ICC)

Reactivity

Human

Overview
Catalog #	bs-6606R-Cy3
Product Name	MRGPRX1/3/4 Polyclonal Antibody, Cy3 Conjugated
Applications	IF(IHC-P), IF(IHC-F), IF(ICC)
Specificity	This may preferentially target MRGPRX1 over 3 and 4 due to slightly higher sequence similarity.
Reactivity	Human
Specifications
Conjugation	Cy3
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human MRGX1
Immunogen Range	21-120/322
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID	259249, 117195, 117196
Subcellular location	Cell membrane
Synonyms	MRGPRC; G protein coupled receptor MRGX1; G protein coupled receptor SNSR3; GPCR; Mas related G protein coupled receptor member X1; MAS related gene MRGX1; MAS related GPR member X1; MRGPRX1; MRGX1; Sensory neuron specic G protein coupled receptor 3/4; Seven transmembrane helix receptor; SNSR3; SNSR4; MRGX1_HUMAN; MRGPRX3; MRGX3; MRGPRX4; MRGX4; SNSR5; SNSR6; SNSR1; SNSR2.
Background	There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G Alpha q- and G Alpha i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G Alpha q-regulated pathways. G Alpha q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.
Application Dilution
IF(IHC-P)	1:50-200
IF(IHC-F)	1:50-200
IF(ICC)	1:50-200

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