Collagen 1, alpha 1 propeptide Antibody
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-70045r |
| Product Name | Collagen 1, alpha 1 propeptide Antibody |
| Applications |
WB
IHC
|
| Specificity | Specific for endogenous levels of the propeptide portion of the ~180 kDa collagen I alpha 1 polypeptide in human lung fibroblast extract. |
| Reactivity | Human, Mouse, Rat |
| Predicted Reactivity | Dog, Bovine, Sheep, Horse, Chicken, Cat, Rabbit, Guinea Pig, Goat, Hamster, Xenopus, Non-Human Primate, Vole, Finch |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Synthetic peptide corresponding to amino acid residues specific to the human collagen 1, alpha 1 propeptide conjugated to keyhole limpet hemocyanin (KLH). |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | Lot dependent |
| Purification | Antigen Affinity purification |
| Storage Buffer | PBS |
| Storage Condition | Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cy |
| Target | |
| Gene ID | 1277 |
| Swiss Prot | P02452 |
| Synonyms | Alpha 1 type I collagen antibody, Alpha 2 type I collagen antibody, alpha 2 type I procollagen antibody, alpha 2(I) procollagen antibody, alpha 2(I)-collagen antibody, Alpha-1 type I collagen antibody, alpha1(I) procollagen antibody, CO1A1_HUMAN antibody, COL1A1 antibody, COL1A2 antibody, collagen alpha 1 chain type I antibody, Collagen alpha-1(I) chain antibody, collagen alpha-1(I) chain preproprotein antibody, Collagen I alpha 1 polypeptide antibody, Collagen I alpha 2 polypeptide antibody, collagen of skin tendon and bone, alpha-1 chain antibody, collagen of skin tendon and bone alpha-2 chain antibody, Collagen type I alpha 1 antibody, Collagen type I alpha 2 antibody, EDSC antibody, OI1 antibody, OI2 antibody, OI3 antibody, OI4 antibody, pro-alpha-1 collagen type 1 antibody, type I proalpha 1 antibody, type I procollagen alpha 1 chain antibody, Type I procollagen antibody |
| Background | Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the first 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005) |
| Application Dilution | |
| WB | 1:300-5000 |
| IHC | |