| Overview |
| bs-70106r |
| GABAA Receptor, 3 (Ser408/409) Antibody |
| WB |
| Specific for endogenous levels of the ~53 kDa GABAA receptor b3 subunit phosphorylated at Ser408/409. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide. |
| Mouse, Rat |
| Human, Dog, Bovine, Chicken, Zebrafish, Xenopus, Non-Human Primate |
| Specifications |
| Unconjugated |
| Rabbit |
| Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser408/409 of the 3 subunit of rat GABAA receptor, conjugated to keyhole limpet hemocyanin (KLH). |
| Ser408,409 |
| Polyclonal |
| #REF! |
| IgG |
| Lot Dependent |
| Antigen Affinity purification from Pooled whole antiserum |
| 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 g per ml BSA and 50% glycerol. |
| Storage at -20C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20C. |
| Target |
| 24922 |
| P63079 |
| ECA5 antibody, GABA alpha receptor beta-2 subunit antibody, GABA(A) receptor subunit beta-3 antibody, GABAA receptor beta 3 subunit antibody, GABAA receptor subunit beta 3 antibody, GABR B3 antibody, Gabrb3 antibody, Gamma aminobutyric acid (GABA) A receptor beta 3 antibody, Gamma aminobutyric acid receptor subunit beta 3 antibody, Gamma-aminobutyric acid receptor subunit beta-3 antibody, GBRB3_HUMAN antibody, MGC9051 antibody |
| Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABA-A and the GABA-B subtype of receptors. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six _s, four _s and four _s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for _- and _-subunits results in the expression of functional GABA-A-Rs sensitive to GABA. However, coexpression of a _-subunit is required for benzodiazepine modulation. Phosphorylation of serine 408 and serine 409 within the _3 subunit have been shown to be critical for the functional modulation of _3 containing recombinant receptors (Brandon et al., 2000). |
| Application Dilution |
| WB |
1:300-5000 |
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