| Overview |
| bs-70177r |
| Nicotinic Acetylcholine Receptor (nAChR) _2 Antibody |
| WB |
| Specific for endogenous levels of the ~52 kDa nAChR_2 protein. |
| Mouse, Rat |
| Specifications |
| Unconjugated |
| Rabbit |
| Fusion protein from the cytoplasmic loop of the _2 subunit of mouse nAChR. |
| Polyclonal |
| #REF! |
| IgG |
| Lot Dependent |
| Antigen Affinity purification from Pooled whole antiserum |
| 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 g per ml BSA and 50% glycerol. |
| Storage at -20C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20C. |
| Target |
| 11444 |
| Q9ERK7 |
| Acetylcholine receptor beta 2 neural antibody, ACHB2_HUMAN antibody, ACHN antibody, AChR antibody, Acrb 2 antibody, Acrb2 antibody, b2 nAchR antibody, Cholinergic receptor nicotinic beta 2 antibody, Cholinergic receptor nicotinic beta polypeptide 2 antibody, Cholinergic receptor nicotinic beta polypeptide 2 neuronal antibody, cholinergic receptor nicotinic beta 2 (neuronal) antibody, Chrnb2 antibody, EFNL 3 antibody, EFNL3 antibody, nAChRB2 antibody, Neuronal acetylcholine receptor protein beta 2 chain precursor antibody, Neuronal acetylcholine receptor protein subunit beta 2 antibody, Neuronal acetylcholine receptor subunit beta-2 antibody, Neuronal nicotinic acetylcholine receptor beta 2 antibody |
| Nicotinic acetylcholine receptors (nAChRs) are ionotropic, cholinergic receptors that are divided into 2 types; muscle type and neuronal type. Neuronal nAChRs are pentameric ion channels consisting of 5 identical (homopentamers) or different (heteropentamers) subunits. Heteropentameric neuronal nAChRs mediate fast synaptic transmission in the autonomic nervous system. The predominant hetero-oligomeric nAChR in the CNS contain the subunits _4_2, whereas _3_4 prevail in the PNS. However, the expression of these subunits varies not only by region but also during development (Scholze et al 2011). In the brain, _2-containing receptors greatly outnumber receptors that contain _4 (McGehee & Role, 1995; Albuquerque, et al., 2009), and in most brain regions, targeted deletion of the _2 subunit virtually abolishes [3H]-epibatidine binding and receptor autoradiography (Zoli, et al., 1998) due to the absence of a _ subunit required to form functional nAChRs (Champtiaux & Changeux, 2004). |
| Application Dilution |
| WB |
1:300-5000 |
Powered by Bioz