Phospholipase C _2 (PLC-_2) Antibody

Applications

Reactivity

Human
Non-Human Primate

Overview
Catalog #	bs-70223r
Product Name	Phospholipase C _2 (PLC-_2) Antibody
Applications	IHC
Specificity	Specific for endogenous levels of PLC _2.
Reactivity	Human, Non-Human Primate
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	Synthetic peptide corresponding to amino acid residues from the C-terminal region of human PLC _2.
Clonality	Polyclonal
Clone #	#REF!
Isotype	IgG
Concentration	Lot Dependent
Purification	Antigen Affinity purification from Pooled whole antiserum
Storage Buffer	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 g per ml BSA and 50% glycerol.
Storage Condition	Storage at -20C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20C.
Target
Gene ID	5330
Swiss Prot	Q00722
Synonyms	1-phosphatidylinositol-4 antibody, 1-phosphatidylinositol-4 5-bisphosphate phosphodiesterase beta-2 antibody, 5-bisphosphate phosphodiesterase beta-2 antibody, FLJ38135 antibody, Phosphoinositide phospholipase C-beta-2 antibody, Phospholipase C-beta-2 antibody, PLC-beta-2 antibody, Plcb2 antibody, PLCB2_HUMAN antibody
Background	Phospholipases are quite common enzymes that are present in a broad range of organisms, including bacteria, yeast, plants, animals, and viruses. Phospholipase C (PLC) constitutes a class of enzymes that cleave phospholipids on the diacylglycerol (DAG) side of the phosphodiester bond (Cocco et al., 2015). A growing body of evidence supports the role of phospholipase C (PLC) in the invasion and metastasis of different tumors, including breast cancer (Bertagnolo et al., 2006). PLC-_2 has been shown to be required for sweet, umami and bitter taste perception in mammals (Zhang et al., 2003). Data also suggests that PLC-_2 serves an unappreciated role assembling components of the p38MAPK signaling module (Barr et al., 2002).
Application Dilution
IHC