Herbimycin A

Overview
Catalog #	bs-75206c-100ug
Product Name	Herbimycin A
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. After reconstitution protect from light at -20°C.
Target
Product Information	CAS Number: 70563-58-5 Molecular formula: C30H42N2O9 Molecular weight: 574.7 Purity: >99% (HPLC) Appearance: Yellow solid. Solubility: Soluble in ethanol, methanol DMSO or dimethylformamide. Poorly soluble in water. InChiKey: MCAHMSDENAOJFZ-JZYYMJJSSA-N SMILES: CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O
Description	Benzoquinone ansamycin antibiotic. Herbicidal compound. Potent, selective, irreversible and cell permeable protein tyrosine kinase inhibitor. Inhibitor of v-Src, Yes, Fps, Ros, Bcr-Abl and ErbB oncogene products. Antitumor compound. Antiangiogenic. Inhibits NF-kappaB activation and phosphorylation of phospholipase C-gamma1. Inhibitor of heat shock protein 90 (Hsp90). Binds Hsp90 and destabilizes client proteins leading to their ubiquitination and proteasomal degradation. Increases the sensitivity of certain cancer cells to chemotherapeutic agents. Neuroprotective. Antiparasitic, antischistosomal agent. Antiviral. Increase microtubules sensitivity to cold in plants.