Convulxin

Overview
Catalog #	bs-75231c-50ug
Product Name	Convulxin
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 37206-04-5 Molecular formula: Molecular weight: ~84kDa Purity: >90% SDS-PAGE (partially purified by multi-step chromatography). Appearance: Lyophilized. Solubility: Soluble in organic buffer (HEPES). InChiKey: MOSFIJXAXDLOML-UHFFFAOYSA-N SMILES:
Description	Glycoprotein GPVI receptor agonist. Can be used for studies on platelet receptors. Activates mammalian platelets via binding and clustering of GPVI-receptors under physiological conditions. Occupation and clustering of GPVI activates Src family kinases, phosphorylates Fc receptor gamma-chain and activates p72SYK that is critical for downstream activation of platelets. Causes cardiovascular and respiratory disturbances. Prostaglandins are strong inhibitors of convulxin-induced aggregation. Heterodimeric C-type lectin. Disulfide linked heterodimer consisting of homologous alpha and beta chains. The heterodimers are additionally linked by disulfide bridges to form cyclic alpha(4)beta(4)heterotetramers.