Bisindolylmaleimide VIII . AcOH [Ro 31-7549]
| Overview | |
| Catalog # | bs-75403c-1mg |
| Product Name | Bisindolylmaleimide VIII . AcOH [Ro 31-7549] |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Target | |
| Product Information | CAS Number: 138516-31-1 Molecular formula: C24H22N4O2 . CH3COOH Molecular weight: 398.5 . 60.1 Purity: >98% (NMR) Appearance: Red powder. Solubility: Soluble in DMSO, methanol or water. Slightly soluble in ethanol. InChiKey: VEOXVBTXROWDAH-UHFFFAOYSA-N SMILES: CC(O)=O.CN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CN(CCCN)C2=C1C=CC=C2 |
| Description | Selective protein kinase C (PKC) inhibitor [1-3]. Inhibits proliferation of cultured mouse epidermal keratinocytes [4]. Enhances Fas- and TRAIL-mediated apoptosis [5, 6]. Inhibits T cell-mediated autoimmune diseases [5]. Inhibits stimulation of insulin secretion by glucose [8]. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2) [7]. |
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