Ds(+)-threo-Isocitric acid . trisodium salt

Overview
Catalog #	bs-75431c-25mg
Product Name	Ds(+)-threo-Isocitric acid . trisodium salt
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Target
Product Information	CAS Number: 903507-52-8 Molecular formula: C6H5O7 . 3Na Molecular weight: 189.1 . 69.0 Purity: >98% (NMR) Appearance: White to off-white solid. Solubility: Soluble in water. InChiKey: HWMVXEKEEAIYGB-UHFFFAOYSA-K SMILES: O[C@H]([C@H](CC(=O)O[Na])C(=O)O[Na])C(=O)O[Na]
Description	Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness. Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome. Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation.