Y-27632 . dihydrochloride
| Overview | |
| Catalog # | bs-75476c-1mg |
| Product Name | Y-27632 . dihydrochloride |
| Specifications | |
| Storage Buffer | Solid |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for 3 months when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 129830-38-2; 146986-50-7 (free base) Molecular formula: C14H21N3O . 2HCl Molecular weight: 247.3 . 72.9 Purity: >98% (HPLC) | Contains approx. 1.4% water. Appearance: White to pale yellow solid. Solubility: Soluble in water, DMSO (25mg/ml) or methanol (25mg/ml). InChiKey: IYOZTVGMEWJPKR-VOMCLLRMSA-N SMILES: C[C@@H](N)C1CCC(CC1)C(=O)NC1=CC=NC=C1 |
| Description | Potent, cell permeable, selective and ATP-competitive Rho-associated protein kinases inhibitor, including p160ROCK, ROCK-II and PRK2 inhibitor [1,3-5]. Tumor cell invasion and metastasis suppressor [2, 15]. Smooth muscle relaxant [1, 6]. Decreases liver fibrosis by hepatic stellate cell growth inhibition [7, 8]. Antinociceptive [9]. Blocks generation of inflammatory cytokines [10]. Stem cell research modulator [11-14, 16]. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated human embryonic stem (hES) cells without affecting their pluripotency. Increases survival rate of hES cells undergoing cryopreservation [11-14, 16]. |
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