cGAMP . 2Na [STING Ligand]
| Overview | |
| Catalog # | bs-75497c-100ug |
| Product Name | cGAMP . 2Na [STING Ligand] |
| Specifications | |
| Storage Buffer | Solid |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. Working aliquots are stable for up to 6 months when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 849214-04-6 (free acid) Molecular formula: C20H24N10O13P2 . 2Na Molecular weight: 674.4 . 46.0 Purity: >98% (HPLC) Appearance: Crystalline solid. Solubility: Soluble in water. InChiKey: MFPHQIYDBUVTRL-HBMYJXICSA-L SMILES: [Na+].[Na+].NC1=NC2=C(N=CN2C2O[C@H]3CO[P@@]([O-])(=O)OC4C(COP([O-])(=O)OC3C2O)O[C@@H](C4O)N2C=NC3=C(N)N=CN=C23)C(=O)N1 |
| Description | Potent STING ligand [2-8]. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA [2-4]. Binding to STING leads to activation of IRF3 (IFN regulatory factor 3) and the induction of interferon-beta [3-6]. First cyclic nucleotide in metazoa [4]. Plays a role in bacterial chemotaxis and colonization [1]. |
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