CK2 Inhibitor 10
| Overview | |
| Catalog # | bs-75525c-1mg |
| Product Name | CK2 Inhibitor 10 |
| Specifications | |
| Storage Buffer | Solid |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 1361229-76-6 Molecular formula: C18H14N2O4S . 0.5H2O Molecular weight: 354.4 . 9.0 Purity: >98% (HPLC, MS, NMR) Appearance: Off-white to pale yellow solid. Solubility: Soluble in DMSO. Insoluble in water. InChiKey: UPIVZLFKYMNZDG-UHFFFAOYSA-N SMILES: COC1=CC=C(C=C1)C(=O)NC1=NC=C(S1)C1=CC=C(C=C1)C(O)=O |
| Description | Potent and ATP-competitive inhibitor of casein kinase 2 (IC50 CK2alpha=32nM and IC50 CK2alpha'=46nM). Potently also inhibits DYRK1B and FLT3. Anticancer compound. Exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116 and breast cancer cells MCF-7. Promoted cAMP-induced thermogenesis in white adipocytes. CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis. |
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