Boceprevir

Overview
Catalog #	bs-75616c-5mg
Product Name	Boceprevir
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 394730-60-0 Molecular formula: C27H45N5O5 Molecular weight: 519.7 Purity: >95% (NMR) Appearance: White to off-white solid. Solubility: Soluble in DMSO (15mg/ml), ethanol (20mg/ml) or DMF (20mg/ml). InChiKey: LHHCSNFAOIFYRV-DOVBMPENSA-N SMILES: [H][C@]1(C2(C)C)[C@]2([H])CN(C([C@H](C(C)(C)C)NC(NC(C)(C)C)=O)=O)[C@]1([H])C(NC(CC3CCC3)C(C(N)=O)=O)=O
Description	The antiviral agent boceprevir is a protease inhibitor that covalently and reversibly binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication (Ki = 14nM) by cleaving the virally encoded polyprotein into mature proteins like NS4A, NS4B, NS5A and NS5B. It inhibits the NS3/4A protease in an in vitro HCV replicon system with an EC50 value of 200 nM. Boceprevir has been identified as a potential inhibitor of SARS-CoV-2 responsible for COVID-19. It inhibits SARS-CoV-2 viral replication by targeting the viral main protease Mpro (IC50 = 4.13µM).