TNIP2 Polyclonal Antibody, PE-Cy5.5 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-7563R-PE-Cy5.5-100uL |
| Product Name | TNIP2 Polyclonal Antibody, PE-Cy5.5 Conjugated |
| Applications |
WB
|
| Reactivity | Human, Rat |
| Predicted Reactivity | Mouse, Dog, Horse |
| Specifications | |
| Conjugation | PE-Cy5.5 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human TNIP2/ABIN2 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 79155 |
| Swiss Prot | Q8NFZ5 |
| Subcellular location | Cytoplasm, Nucleus |
| Synonyms | KLIP; ABIN2; FLIP1; TNFAIP3-interacting protein 2; A20-binding inhibitor of NF-kappa-B activation 2; ABIN-2; Fetal liver LKB1-interacting protein; TNIP2 |
| Background | Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. |
| Application Dilution | |
| WB | 1:300-5000 |
Frequently asked questions
Which applications is TNIP2 Polyclonal Antibody, PE-Cy5.5 Conjugated (BS-7563R-PE-CY5-5) validated for, and at what dilution?
BS-7563R-PE-CY5-5 is validated for WB (1:300-5000). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does TNIP2 Polyclonal Antibody, PE-Cy5.5 Conjugated (BS-7563R-PE-CY5-5) react with?
Tested reactivity: Human, Rat. Predicted reactivity (expected from sequence homology but not yet tested): Mouse, Dog, Horse.
How should BS-7563R-PE-CY5-5 be stored?
Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise TNIP2 Polyclonal Antibody, PE-Cy5.5 Conjugated (BS-7563R-PE-CY5-5)?
KLH conjugated synthetic peptide derived from human TNIP2/ABIN2
What are the excitation and emission wavelengths of the PE-Cy5.5 conjugate (BS-7563R-PE-CY5-5)?
PE-Cy5.5 on BS-7563R-PE-CY5-5: excitation / emission 488nm/694nm.