Cabozantinib S-malate
| Overview | |
| Catalog # | bs-76092c-100mg |
| Product Name | Cabozantinib S-malate |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Stable for 2 years after receipt when stored at +4°C. |
| Target | |
| Product Information | CAS Number: 1140909-48-3 Molecular formula: C32H30FN3O10 Molecular weight: 635.59 Purity: >99% (HPLC) Appearance: White to off white crystalline powder. Solubility: Soluble in DMSO. InChiKey: HFCFMRYTXDINDK-WNQIDUERSA-N SMILES: O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC(C=C3)=CC=C3OC4=CC=NC5=CC(OC)=C(OC)C=C54.O=C(O)C[C@H](O)C(O)=O SMILES: O[C@@H](CC(O)=O)C(O)=O.COC1=C(OC)C=C2C(OC3=CC=C(NC(=O)C4(CC4)C(=O)NC4=CC=C(F)C=C4)C=C3)=CC=NC2=C1 |
| Description | The s-malate salt form of Cabozantinib is very potent orally available inhibitor of multiple receptor tyrosine kinases (RTK), specifically MET and VEGFR2. It also inhibits KIT, FLT3, Tie-2, RET and AXL. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature, angiogenesis and extensive tumor cell apoptosis. |
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