Anthralin

Overview
Catalog #	bs-76195c-1g
Product Name	Anthralin
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 1143-38-0 Molecular formula: C14H10O3 Molecular weight: 226.2 Purity: >98% (HPLC) Appearance: Faint yellow to yellow powder. Solubility: Soluble in acetone. InChiKey: NUZWLKWWNNJHPT-UHFFFAOYSA-N SMILES: OC1=CC=CC2=C1C(=O)C1=C(O)C=CC=C1C2 SMILES: OC1=C2C(CC3=CC=CC(O)=C3C2=O)=CC=C1
Description	Anthralin is a leukotriene biosynthesis inhibitor. It inhibits LTB4 omega-oxidation and disrupts mitochondria function. Anthralin is used in the treatment of psoriasis, as a fungicide, in the treatment of ringworm infections and in chronic dermatoses. It accumulates in mitochondria where it interferes with the supply of energy to the cell, probably by the oxidation of dithranol releasing free radicals. This impedes DNA replication and so slows the excessive cell division that occurs in psoriatic plaques. Numerous studies have demonstrated anti-proliferative and anti-inflammatory effects of anthralin on psoriatic and normal skin. It is also used as matrix substance for MALDI-MS (matrix-assisted laser desorption ionization MS).