N-Dodecanoyl-DL-homoserine lactone
| Overview | |
| Catalog # | bs-76211c-10mg |
| Product Name | N-Dodecanoyl-DL-homoserine lactone |
| Specifications | |
| Storage Buffer | Solid |
| Storage Condition | Stable for 2 years after receipt when stored at +4°C. |
| Target | |
| Product Information | CAS Number: 18627-38-8 Molecular formula: C16H29NO3 Molecular weight: 283.4 Purity: >97% (GC) Appearance: White solid. Solubility: Soluble in chloroform. InChiKey: WILLZMOKUUPJSL-UHFFFAOYSA-N SMILES: CCCCCCCCCCCC(=O)NC1CCOC1=O SMILES: CCCCCCCCCCCC(=O)NC1CCOC1=O |
| Description | N-Dodecanoyl-DL-homoserine lactone (C12-HSL) is a small diffusible signalling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. In addition to regulating bacterial functions, C12-HSL activates NF-kappaB in RAW 264.7 macrophages, increasing the expression of TNF-alpha, interleukin-1beta (IL-1beta) and IL-8, while other lactones do not. In addition, C12-HSL alters cell cycling and metabolism of human keratinocyte (HaCaT) cells. It also was shown to induce cell death by apoptosis. |
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