Ganciclovir

Overview
Catalog #	bs-76357c-100mg
Product Name	Ganciclovir
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 82410-32-0 Molecular formula: C9H13N5O4 Molecular weight: 255.23 Purity: >99% (HPLC) Appearance: White to light yellow powder. Solubility: Soluble in 0.1 N HCl (10mg/ml). Slightly soluble in DMSO (1mg/ml). InChiKey: IRSCQMHQWWYFCW-UHFFFAOYSA-N SMILES: O=C1C2=C(N(COC(CO)CO)C=N2)N=C(N)N1 SMILES: NC1=NC2=C(N=CN2COC(CO)CO)C(=O)N1
Description	Ganciclovir is antiviral synthetic analog of the nucleoside 2'-deoxy-guanosine, which is used to treat or prevent cytomegalovirus (CMV) infections. It acts as a prodrug activated by phosphorylation. It is first phosphorylated to ganciclovir monophosphate by a viral kinase encoded by the cytomegalovirus (CMV) gene UL97 during infection. Subsequently, cellular kinases catalyze the formation of ganciclovir diphosphate and ganciclovir triphosphate. Ganciclovir triphosphate is a competitive inhibitor of deoxyguanosine triphosphate (dGTP) incorporation into DNA and preferentially inhibits viral DNA polymerases more than cellular DNA polymerases. It is also useful in the study of gene therapy in cancer research. Ganciclovir has been used in the study of "suicide" gene therapy in cancer research, where upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Ganciclovir has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents.