Hesperidin

Overview
Catalog #	bs-76432c-25g
Product Name	Hesperidin
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 520-26-3 Molecular formula: C28H34O15 Molecular weight: 610.56 Purity: >98% (HPLC) Appearance: Beige to light brown powder. Solubility: Soluble in DMSO (5mg/ml), DMF (3mg/ml) or pyridine (50mg/ml). InChiKey: QUQPHWDTPGMPEX-QJBIFVCTSA-N SMILES: O=C1C[C@@H](C2=CC=C(OC)C(O)=C2)OC3=CC(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4)=CC(O)=C31 SMILES: COC1=C(O)C=C(C=C1)[C@@H]1CC(=O)C2=C(O1)C=C(O[C@@H]1O[C@H](CO[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]1O)C=C2O
Description	Hesperidin is a flavanone rutinoside first isolated from citrus peels. It is metabolized by intestinal bacteria to an aglycone form, hesperetin, which is thought to be more bioavailable due to reduced polarity that allows for increased cell permeability. Both hesperidin (Hsd) and its aglycone hesperetin (Hst) have various biological properties. Studies have shown both anti-cancer and cancer chemopreventive effects, associated with their antioxidant, radical scavenging and anti-inflammatory activities. In addition, Hsd and Hst interfere at different stages of cancer. They inhibit tumor growth by targeting multiple cellular protein targets at the same time, including caspases, Bcl-2 and Bax for the induction of apoptosis, and COX-2, MMP-2 and MMP-9 for the inhibition of angiogenesis and metastasis. They also have show cardioprotective, neuroprotective and antimicrobial effects. Antiviral, potential inhibitor against SARS-CoV-2 infection.