Hederacoside C

Overview
Catalog #	bs-76438c-50mg
Product Name	Hederacoside C
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 14216-03-6 Molecular formula: C59H96O26 Molecular weight: 1221.38 Purity: >98% (HPLC) Appearance: White powder. Solubility: Soluble in DMSO (5mg/ml), DMF (15mg/ml) or ethanol (10mg/ml). InChiKey: RYHDIBJJJRNDSX-MCGLQMIESA-N SMILES: O=C(O[C@H](O[C@@H]1CO[C@H](O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]2O[C@@](O[C@H]3C)([H])[C@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@@H](O)[C@@H]1O)[C@@]4(CC5)CC[C@]6(C)C([C@]4([H])CC5(C)C)=CC[C@@]7([H])[C@@]6(C)CC[C@]8([H])[C@]7(C)CC[C@H](O[C@@](OC[C@@H]9O)([H])[C@]([C@H]9O)([H])O[C@H](O[C@H]%10C)[C@H](O)[C@H](O)[C@H]%10O)[C@@]8(C)CO SMILES: C[C@@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](OC[C@H]3O[C@@H](OC(=O)[C@]45CCC(C)(C)C[C@H]4C4=CC[C@@H]6[C@@]7(C)CC[C@H](O[C@@H]8OC[C@H](O)[C@H](O)[C@H]8O[C@@H]8O[C@@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@@](C)(CO)[C@@H]7CC[C@@]6(C)[C@]4(C)CC5)[C@H](O)[C@@H](O)[C@@H]3O)O[C@@H]2CO)[C@H](O)[C@H](O)[C@H]1O
Description	Hederacoside C is a major bioactive constituent isolated from Hedera helix L. It exhibits biological properties such as antibacterial, expectorant, bronchodilator, bronchospasmolytic and anti-inflammatroy effects. It is widely used in the treatment of respiratory disorders involving acute respiratory infections, chronic inflammatory bronchitis and productive coughs. It reduces TNF-alpha, IL-1beta, IL-6, COX-2, and nitric oxide synthase (NOS) levels in a concentration-dependent manner and IL-1 receptor-associated kinase-1 (IRAK1) activity. It reduces scopolamine-induced memory impairment. Hederacoside C markedly suppressed TLR2 and TLR4 expressions by attenuating the MAPKs (p38, ERK, JNK) and NF-kappa (p65 and IkappaBalpha) pathways followed by decreasing the phosphorylation of p38, ERK, JNK, p65, and IkappaBalpha.