Isorhamnetin

Overview
Catalog #	bs-76471c-5mg
Product Name	Isorhamnetin
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 480-19-3 Molecular formula: C16H12O7 Molecular weight: 316.26 Purity: >98% (HPLC) Appearance: Beige to light yellow powder. Solubility: Soluble in DMSO (20mg/ml) or DMF (10mg/ml). InChiKey: IZQSVPBOUDKVDZ-UHFFFAOYSA-N SMILES: O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=C(O)C(OC)=C3)=C1O SMILES: COC1=C(O)C=CC(=C1)C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1
Description	Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin. It shows diverse biological activities, including antioxidant, cardioprotective, anti-inflammatory, neuroprotective, antiobesity, antiviral, antituberculosis and anticancer properties. Isorhamnetin exerts anticancer activity, through induction of apoptosis and inhibition of cell proliferation and invasion. It suppresses colon cancer cell growth through the PI3K-Akt-mTOR pathway. It inhibits the NF-kappaB signaling pathway. Isorhamnetin selectively inhibited NLRP3 and AIM2 inflammasome activation and down-regulated expression of pro-inflammatory cytokines. It has powerful antioxidant action through its ability to scavenge free radicals and inhibits xanthine oxidase. Isorhamnetin is a PPARgamma antagonist and inhibits adipogenesis, with beneficial effect on the prevention and treatment of obesity.