Mildronate dihydrate
| Overview | |
| Catalog # | bs-76570c-10mg |
| Product Name | Mildronate dihydrate |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 86426-17-7 Molecular formula: C6H14N2O2 . 2H2O Molecular weight: 182.22 Purity: >98% (HPLC) Appearance: White to off-white powder. Solubility: Soluble in water (20mg/ml) or ethanol (20mg/ml). InChiKey: PVBQYTCFVWZSJK-UHFFFAOYSA-N SMILES: [O-]C(CCN[N+](C)(C)C)=O |
| Description | Mildronate is a structural analog of gamma-butyrobetaine (gammaBB), an intermediate in the biosynthesis of carnitine and a modulator of energy metabolism. It blocks carnitine synthesis by inhibiting gammaBB hydroxylase (BBOX) and, less potently, carnitine acetyltransferase (CrAT). Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine. This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective, antidiabetic and neuroprotective effects. Mildronate also improves cognition and reduces amyloid-beta pathology in a mouse model of Alzheimer’s disease. |
Frequently asked questions
Which applications is Mildronate dihydrate (bs-76570C) validated for, and at what dilution?
bs-76570C is validated for Life Science( N/A).
How should bs-76570C be stored?
Stable for 2 years after receipt when stored at -20°C. Storage buffer: Powder