Osthole

Overview
Catalog #	bs-76662c-10mg
Product Name	Osthole
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at RT.
Target
Product Information	CAS Number: 484-12-8 Molecular formula: C15H16O3 Molecular weight: 244.29 Purity: >95% (HPLC) Appearance: White to off-white powder. Solubility: Soluble in DMSO, DMF, ethanol (all 20mg/ml) or methanol (10mg/ml). InChiKey: MBRLOUHOWLUMFF-UHFFFAOYSA-N SMILES: O=C1OC2=C(C/C=C(C)/C)C(OC)=CC=C2C=C1
Description	Osthole is a natural coumarin that was first isolated from several medicinal plants, including C. monnieri and A. pubescens. Osthole exhibits immunomodulatory, antioxidative, and anti-inflammatory properties, by regulating the expression of TNF-alpha, NF-kappaB, TGF-beta, cyclooxygenases, leukotrienes, nitric oxide, ERK and JNK. Shows also anti-cancer, chemopherapeutic, analgesic, neuroprotective, antipruritic, anti-leishmania and anti-lipedemic activities. It is reported to induce a nonspecific elevation of cAMP and cGMP levels through its ability to inhibit phosphodiesterases, which leads to a modulation of calcium channel signaling and vasorelaxant effects. Selectively inhibits TRPV3 channels in skin. Induces apoptosis and cell cycle arrest in cancer cells. Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.