Phlorizin

Overview
Catalog #	bs-76717c-250mg
Product Name	Phlorizin
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 60-81-1 Molecular formula: C21H24O10 Molecular weight: 436.413 Purity: >98% (HPLC) Appearance: Light yellow to off-white powder. Solubility: Soluble in DMSO (20mg/ml), DMF (20mg/ml) or ethanol (5mg/ml). InChiKey: IOUVKUPGCMBWBT-RQUKQETFSA-N SMILES: OC1=CC=C(CCC(C2=C(O)C=C(O)C=C2O[C@@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O3)=O)C=C1 SMILES: OC[C@H]1O[C@@H](OC2=C(C(=O)CCC3=CC=C(O)C=C3)C(O)=CC(O)=C2)[C@H](O)[C@@H](O)[C@@H]1O
Description	Phlorizin is a natural product, first isolated from the bark of apple trees, that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through inhibition of SGLT1 and SGLT2. It competitively inhibits (competes with D-glucose) the initial rate of alpha-methyl-D-glucopyranoside (alpha-MDG) uptake in the nM range. Phlorizin has been shown to enhance insulin sensitivity and to have antioxidant properties. Sodium-glucose cotransporter 1 (SGLT1) is a high affinity, low capacity transporter abundant in the small intestine, with some expression in the kidney as well. SGLT2 is a low affinity, high capacity transporter in the kidney that accounts for approximately 90% of glucose reabsorption into the blood stream. Selective inhibition of SGLT2 is a potential strategy for reducing plasma glucose levels as a treatment for diabetes.