Sodium salicylate

Overview
Catalog #	bs-76794c-25g
Product Name	Sodium salicylate
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at RT.
Target
Product Information	CAS Number: 54-21-7 Molecular formula: C7H5O3 . Na Molecular weight: 160.1 Purity: >99% (dried substance) Appearance: White to off-white crystalline powder. Solubility: Soluble in water (50mg/ml) or ethanol. InChiKey: ABBQHOQBGMUPJH-UHFFFAOYSA-M SMILES: OC1=C(C(O[Na])=O)C=CC=C1 SMILES: [Na+].OC1=C(C=CC=C1)C([O-])=O
Description	Sodium salicylate is a metabolite of aspirin. It is a cell-permeable, non-steroidal anti-inflammatory agent (NSAID) that interferes with TNF-induced NF-kappaB activation by inhibiting phosphorylation and subsequent degradation of the IkappaB-alpha protein. It selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases and TNF-induced activation of JNK. It induces apoptosis via p38 kinase activation and inhibits COX-2 and inducible NOS (iNOS) transcription dependent on the experimental setup. It is commonly used for its antipyretic, anti-oxidant, neuroprotective, anti-inflammatory, anti-cancer and analgesic properties.