Silibinin
| Overview | |
| Catalog # | bs-76795c-10g |
| Product Name | Silibinin |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 22888-70-6 Molecular formula: C25H22O10 Molecular weight: 482.44 Purity: >98% (HPLC) Appearance: White to slightly yellow powder. Solubility: Soluble in DMSO (10mg/ml) or DMF (20mg/ml). InChiKey: SEBFKMXJBCUCAI-PQVVKJAFSA-N SMILES: OC1=C2C(O[C@@H](C3=CC=C(O[C@@H](CO)[C@H](C4=CC=C(O)C(OC)=C4)O5)C5=C3)[C@H](O)C2=O)=CC(O)=C1 SMILES: COC1=C(O)C=CC(=C1)[C@H]1OC2=C(O[C@@H]1CO)C=CC(=C2)[C@H]1OC2=C(C(O)=CC(O)=C2)C(=O)[C@@H]1O |
| Description | Silibinin is a naturally occurring flavanone from Silybum marianum (milk thistle plant) and the main component (active principle) of the Silymarin extract. Silibinin has shown pleiotropic biological properties, including potent antioxidant, anti-inflammatory, anticancer, antidiabetic, hepatoprotective, neuroprotective, antiviral, antimicrobial and immunosuppressive activities. Silibinin demonstrates promising anticancer effects in vitro and in vivo. The molecular mechanisms of silibinin-mediated antiproliferative effects are mainly via receptor tyrosine kinases, androgen receptor, STATs, NF-kappaB, cell cycle arrest and apoptotis/autophagy inducing signaling pathways in various cancer cells. Silibinin was reported to improve glycemic homeostasis by improving the activity of pancreatic beta-cells, increasing insulin sensitivity of liver and muscle cells and decreasing lipid deposition in adipocytes. Next to modulating the NFkappa signaling pathway, Sibilin also inhibits NLRP1/NLRP3 inflammasomes signaling pathways. It modulates many molecular changes caused by xenobiotics and ultraviolet radiation to protect the skin and is used in cosmeceutical preparations. |
Frequently asked questions
Which applications is Silibinin (bs-76795C) validated for, and at what dilution?
bs-76795C is validated for Life Science( N/A).
How should bs-76795C be stored?
Stable for 2 years after receipt when stored at -20°C. Storage buffer: Powder