RBM38 Polyclonal Antibody, Biotin Conjugated

Applications

  • ELISA
  • IHC-P
  • IHC-F

Predicted Reactivity

  • Human
  • Mouse
  • Rat
  • Dog
  • Cow
  • Pig
  • Chicken
  • Rabbit
Overview
Catalog # bs-7682R-Biotin
Product Name RBM38 Polyclonal Antibody, Biotin Conjugated
Applications ELISA, IHC-P, IHC-F
Predicted Reactivity Human, Mouse, Rat, Dog, Cow, Pig, Chicken, Rabbit
Specifications
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic peptide derived from human RBM38
Immunogen Range 51-150/239
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 55544
Subcellular location Cytoplasm, Nucleus
Synonyms SEB4D; CLL associated antigen KW 5; CLL-associated antigen KW-5; HSRNASEB; RBM38; RBM38_HUMAN; RNA binding mot protein 38; RNA binding protein 38; RNA binding region RNP1, RRM containing 1; RNA binding region containing protein 1; RNA-binding mot protein 38; RNA-binding protein 38; RNA-binding region-containing protein 1; RNPC1; SEB4; SEB4B; ssDNA binding protein SEB4; ssDNA-binding protein SEB4.
Background RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.
Application Dilution
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500