GSK-J4
| Overview | |
| Catalog # | bs-82219c-5mg |
| Product Name | GSK-J4 |
| Specifications | |
| Storage Buffer | Yellow waxy solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2. |
| Description | CAS Number: 1373423-53-0 Chemical Name: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester Molecular weight: 417.48 Formula: C24H27N5O2 Solubility: DMSO (40 mg/ml) Ethanol (40 mg/ml) Physical Properties: Yellow waxy solid Purity: 99% by TLC, NMR (Conforms) |
Frequently asked questions
Which applications is GSK-J4 (bs-82219C) validated for, and at what dilution?
bs-82219C is validated for Life Science( N/A).
How should bs-82219C be stored?
-20°C Storage buffer: Yellow waxy solid